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Journal article

Iron load and redox stress in skeletal muscle of aged rats.

Abstract:

Loss of skeletal muscle mass (sarcopenia) is a major contributor to disability in old age. We used two-dimensional gel electrophoresis and mass spectrometry to screen for changes in proteins, and cDNA profiling to assess transcriptional regulations in the gastrocnemius muscle of adult (4 months) and aged (30 months) male Sprague-Dawley rats. Thirty-five proteins were differentially expressed in aged muscle. Proteins and mRNA transcripts involved in redox homeostasis and iron load were increas...

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Publication status:
Published

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Publisher copy:
10.1002/mus.20808

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Journal:
Muscle and nerve
Volume:
36
Issue:
2
Pages:
223-233
Publication date:
2007-08-05
DOI:
EISSN:
1097-4598
ISSN:
0148-639X
URN:
uuid:efe3a079-0964-4b54-9ba3-df29e7903d7e
Source identifiers:
16053
Local pid:
pubs:16053

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