A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

Journal article

In a backcross population (n = 281) derived from a cross of the Lyon hypertensive rat with Lyon normotensive rat, we investigated whether genetic factors influence the acute cardiovascular responses to pharmacological modulation of the renin-angiotensin system, the sympathetic nervous system, and the voltage-sensitive L-type calcium channels. Using microsatellite markers, a quantitative trait locus was identified and mapped on rat chromosome 2 that specifically influences the systolic (peak L...

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Authors: Vincent, M; Samani, N; Gauguier, D; Thompson, JR; Lathrop, G

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 100
• Issue: 8
• Pages: 2000-2006
• Publication date: 1997-10-01
• DOI: 10.1172/jci119731
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Microsatellite Repeats; Diastole; Phenotype; Animals; Crosses, Genetic; Quantitative Trait, Heritable; Hypertension; Rats; Male; Lod Score; Chromosome Mapping; Renin-Angiotensin System; Calcium Channels, L-Type; Systole; Calcium Channel Blockers; Disease Models, Animal; Blood Pressure; Sympathetic Nervous System; Female; Nifedipine; Calcium Channels