Journal article icon

Journal article

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb.

Abstract:

One of the common features of cellular response to stress is cell cycle arrest or apoptosis. E2F is one of the key factors which controls cell cycle progression. Overexpression of E2F-1 can also induce apoptosis. In order to understand the role of E2F-1 in cellular response to stress, we studied the E2F-1 response in various cell lines to different types of stress signals including UV irradiation, cisplatin, etoposide and hypoxia. We showed here that the expression level of E2F-1 can be up re...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.onc.1203540

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
Oncogene
Volume:
19
Issue:
20
Pages:
2369-2376
Publication date:
2000-05-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:efd4c298-0bed-43cf-bf84-66987905a49d
Source identifiers:
83944
Local pid:
pubs:83944

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP