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Improving the microbiological diagnosis of tuberculous meningitis: A prospective, international, multicentre comparison of conventional and modified Ziehl–Neelsen stain, GeneXpert, and culture of cerebrospinal fluid

Abstract:
Objectives Tuberculous meningitis (TBM) is the severest form of tuberculosis, but current diagnostic tests are insensitive. Recent reports suggest simple modifications to conventional cerebrospinal fluid (CSF) Ziehl–Neelsen (ZN) staining may greatly improve sensitivity. We sought to define the performance of modified and conventional ZN stain for TBM diagnosis. Methods In hospitals in Vietnam, South Africa and Indonesia we conducted a prospective study o... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.jinf.2018.09.003

Authors


Heemskerk, AD More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Chaidir, L More by this author
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Grant:
(Vietnam grant number: 106680/Z/14/Z
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Grant:
USAID-NAS Project (Indonesia, sub-grant number: 2000003601
Publisher:
Elsevier Publisher's website
Journal:
Journal of Infection Journal website
Publication date:
2018-09-12
Acceptance date:
2018-09-07
DOI:
ISSN:
0163-4453
Pubs id:
pubs:917749
URN:
uri:efd3664f-1868-4e6b-b9ae-bd150be39816
UUID:
uuid:efd3664f-1868-4e6b-b9ae-bd150be39816
Local pid:
pubs:917749

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