Journal article

Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

Abstract:: Side effects account for most of the instances of failure of candidate drugs at late stages of development. These development failures contribute to the exorbitant cost of bringing new compounds to market: a single withdrawal can represent a loss of more than 1 billion. Many unwanted actions of drugs affect the heart, resulting in potentially proarrhythmic alteration of ion channel function. Because these can be fatal, potential electrophysiological

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APA Style

Rodriguez, B., Burrage, K., Gavaghan, D., Grau, V., Kohl, P., & Noble, D. (2010). Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs. CLINICAL PHARMACOLOGY and THERAPEUTICS    , 88(1), 130–134.

MLA Style

Rodriguez, B, et al. “Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs.” CLINICAL PHARMACOLOGY and THERAPEUTICS    , vol. 88, no. 1, 2010, pp. 130–34.

Chicago Style

Rodriguez, B, K Burrage, D Gavaghan, V Grau, P Kohl, and D Noble. 2010. “Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs.” CLINICAL PHARMACOLOGY and THERAPEUTICS     88 (1): 130–34.
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Authors

+ Rodriguez, B More by this author

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+ Burrage, K More by this author

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+ Gavaghan, D More by this author

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+ Grau, V More by this author

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+ Kohl, P More by this author

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Journal:: CLINICAL PHARMACOLOGY and THERAPEUTICS More from this journal
Volume:: 88
Issue:: 1
Pages:: 130-134
Publication date:: 2010-07-01

UUID:: uuid:efd2032c-08d1-4a5a-bc64-583f0863c998
Local pid:: cs:4221
Deposit date:: 2015-03-31
ARK identifier:: ark:/29072/ora_efd2032c08d14a5abc64583f0863c998

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Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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