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Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

Abstract:
Side effects account for most of the instances of failure of candidate drugs at late stages of development. These development failures contribute to the exorbitant cost of bringing new compounds to market: a single withdrawal can represent a loss of more than 1 billion. Many unwanted actions of drugs affect the heart, resulting in potentially proarrhythmic alteration of ion channel function. Because these can be fatal, potential electrophysiological

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B. Rodriguez More by this author
K. Burrage More by this author
DJ Gavaghan More by this author
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Journal:
CLINICAL PHARMACOLOGY and THERAPEUTICS
Volume:
88
Issue:
1
Pages:
130-134
Publication date:
2010-07-01
URN:
uuid:efd2032c-08d1-4a5a-bc64-583f0863c998
Local pid:
cs:4221

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