Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

Journal article

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

Authors: Kündig, T; Bachmann, M; DiPaolo, C; Simard, J; Battegay, M

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 268
• Issue: 5215
• Pages: 1343-1347
• Publication date: 1995-06-01
• DOI: 10.1126/science.7761853
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Animals; Mice, Inbred C57BL; Transfection; Mice; Lymphoid Tissue; Viral Proteins; Tumor Cells, Cultured; Fibroblasts; Lymphocytic choriomeningitis virus; L Cells (Cell Line); Cytotoxicity, Immunologic; Neoplasms; T-Lymphocytes, Cytotoxic; Lymphocytic Choriomeningitis; Glycoproteins; Antigen-Presenting Cells; Histocompatibility Antigens Class I