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A 10-megabase physical map of human Xp21, including the Duchenne muscular dystrophy gene.

Abstract:

Using pulsed-field gel electrophoresis and 12 Xp21-derived DNA probes, we have constructed a continuous restriction map spanning more than 4 million base pairs (4 Mbp), including the Duchenne muscular dystrophy gene of more than 2 Mbp. This detailed map is part of a less detailed map spanning 10 Mbp, also spanning the genes for glycerol kinase and congenital adrenal hypoplasia, constructed under electrophoresis conditions which separated DNA fragments in the range 200 to 4000 kbp. DNA from th...

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Authors


Burmeister, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Gillard, EF More by this author
van Ommen, GJ More by this author
Affara, NA More by this author
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Journal:
Genomics
Volume:
2
Issue:
3
Pages:
189-202
Publication date:
1988-04-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:efbe5282-3e44-45f9-9cb3-c60576c5c385
Source identifiers:
115683
Local pid:
pubs:115683

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