Journal article

Metal-free oxidative fluorination of phenols with [18F]fluoride.

Abstract:: The radiochemical synthesis of [18F]4-fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra-n-butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O-unprotected 4-tert-butyl phenols are used as precursors in this one-pot protocol. The reaction is completed in less than 30 minutes at room temperature and can be performed using standard or microfluidic technology. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Gao, Z., Lim, Y., Tredwell, M., Li, L., Verhoog, S., Hopkinson, M., Kaluza, W., Collier, T., Passchier, J., Huiban, M., & Gouverneur, V. (2012). Metal-free oxidative fluorination of phenols with [18F]fluoride. Angewandte Chemie (International Ed. in English), 51(27), 6733–6737.

MLA Style

Gao, Z., et al. “Metal-Free Oxidative Fluorination of Phenols with [18F]Fluoride.” Angewandte Chemie (International Ed. in English), vol. 51, no. 27, 2012, pp. 6733–37.

Chicago Style

Gao, Z, Y Lim, M Tredwell, L Li, S Verhoog, M Hopkinson, W Kaluza, et al. 2012. “Metal-Free Oxidative Fluorination of Phenols with [18F]Fluoride.” Angewandte Chemie (International Ed. in English) 51 (27): 6733–37.
Share
Print

Access Document

Publisher copy:: 10.1002/anie.201201502

Authors

+ Gao, Z More by this author

Role:: Author

+ Lim, Y More by this author

Role:: Author

+ Tredwell, M More by this author

Role:: Author

+ Li, L More by this author

Role:: Author

+ Verhoog, S More by this author

Role:: Author

More authors...

Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 51
Issue:: 27
Pages:: 6733-6737
Publication date:: 2012-07-01
DOI:: 10.1002/anie.201201502
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: Isotope Labeling

Radiopharmaceuticals

Positron-Emission Tomography

Hydrocarbons, Fluorinated

Phenols

Fluorine Radioisotopes
Pubs id:: pubs:334720
UUID:: uuid:efbda8be-25ad-4ed1-b947-cc72f77ece15
Local pid:: pubs:334720
Source identifiers:: 334720
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP