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Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1

Abstract:

Factor H-binding protein (fHbp) is an important meningococcal vaccine antigen. Native outer membrane vesicles with over-expressed fHbp (NOMV OE fHbp) have been shown to induce antibodies with broader functional activity than recombinant fHbp (rfHbp). Improved understanding of this broad coverage would facilitate rational vaccine design. We performed a pair-wise analysis of 48 surface-exposed amino acids involved in interacting with factor H, among 383 fHbp variant group 1 sequences. We genera...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0181508

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Department:
Oxford, MSD, NDM, Jenner Institute
Rondini, S More by this author
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Grant:
Marie Curie Actions FP7/2007- 2013/REA n˚316940
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
7
Pages:
Article: e0181508
Publication date:
2017-07-25
DOI:
ISSN:
1932-6203
Pubs id:
pubs:709520
URN:
uri:efb89fbe-aede-4444-aba0-a581682e48f5
UUID:
uuid:efb89fbe-aede-4444-aba0-a581682e48f5
Local pid:
pubs:709520
Language:
English
Keywords:

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