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Genetic architecture of quantitative traits in mice, flies, and humans.

Abstract:

We compare and contrast the genetic architecture of quantitative phenotypes in two genetically well-characterized model organisms, the laboratory mouse, Mus musculus, and the fruit fly, Drosophila melanogaster, with that found in our own species from recent successes in genome-wide association studies. We show that the current model of large numbers of loci, each of small effect, is true for all species examined, and that discrepancies can be largely explained by differences in the experiment...

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Publication status:
Published

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Publisher copy:
10.1101/gr.086660.108

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Mackay, TF More by this author
Journal:
Genome research
Volume:
19
Issue:
5
Pages:
723-733
Publication date:
2009-05-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:efb2a816-d5b5-4bfe-977f-db8a2282c233
Source identifiers:
34706
Local pid:
pubs:34706

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