Adherence to both cotrimoxazole and placebo is associated with improved survival among HIV-infected Zambian children.

Journal article

In the CHAP randomized placebo-controlled trial of cotrimoxazole prophylaxis in HIV-infected Zambian children conducted between 2001 and 2003, cotrimoxazole was associated with significant mortality reductions. In a secondary analysis we used Cox regression models to estimate the association between adherence measured by bottle weights and caregiver report and subsequent mortality in children surviving >28 days (n = 496, 153 deaths). Adherence was high and similar in both cotrimoxazole and...

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Authors: Walker, A; Ford, D; Mulenga, V; Thomason, M; Nunn, A

• Publication status: Published
• Journal: AIDS and behavior
• Volume: 13
• Issue: 1
• Pages: 33-41
• Publication date: 2009-02-01
• DOI: 10.1007/s10461-008-9382-4
• EISSN: 1573-3254
• ISSN: 1090-7165
• Language: English
• Keywords: Child; Adolescent; Child, Preschool; AIDS-Related Opportunistic Infections; Infant; Trimethoprim-Sulfamethoxazole Combination; Anti-Infective Agents; Caregivers; Survival Analysis; Zambia; Medication Adherence; Humans; Pneumonia, Pneumocystis