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Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

Abstract:

The sesquiterpenoids are a large class of naturally occurring compounds with biological functions and desirable properties. Oxidation of the sesquiterpene (+)-valencene by wild type and mutants of P450cam from Pseudomonas putida, and of P450BM-3 from Bacillus megaterium, have been investigated as a potential route to (+)-nootkatone, a fine fragrance. Wild type P450cam did not oxidise (+)-valencene but the mutants showed activities up to 9.8 nmol (nmol P450)(-1) min(-1), with (+)-trans-nootkat...

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Publication status:
Published

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Publisher copy:
10.1039/b413068e

Authors


Sowden, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Journal:
Organic and biomolecular chemistry
Volume:
3
Issue:
1
Pages:
57-64
Publication date:
2005-01-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:efa5f634-169e-4b69-8d29-13979d29feb4
Source identifiers:
32934
Local pid:
pubs:32934

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