Antibodies inhibit prion propagation and clear cell cultures of prion infectivity.

Journal article

Prions are the transmissible pathogenic agents responsible for diseases such as scrapie and bovine spongiform encephalopathy. In the favoured model of prion replication, direct interaction between the pathogenic prion protein (PrPSc) template and endogenous cellular prion protein (PrPC) is proposed to drive the formation of nascent infectious prions. Reagents specifically binding either prion-protein conformer may interrupt prion production by inhibiting this interaction. We examined the abil...

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Authors: Peretz, D; Williamson, R; Kaneko, K; Vergara, J; Leclerc, E

• Publication status: Published
• Journal: Nature
• Volume: 412
• Issue: 6848
• Pages: 739-743
• Publication date: 2001-08-01
• DOI: 10.1038/35089090
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Recombinant Proteins; Escherichia coli; Animals; Tumor Cells, Cultured; PrPC Proteins; Immunoglobulin Fragments; Epitopes, B-Lymphocyte; Antibody Specificity; Mice; Biological Assay; Prions