Conference item
Loss of programmed death ligand-1 expression on donor T cells lessens acute graft-versus-host disease lethality
- Abstract:
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The PD-1/PD-L1 pathway plays an important role in regulation of alloimmune responses and in induction and maintenance of peripheral tolerance. Because GVHD is driven by donor T cells and PD-L1 expression can be markedly elevated on T cells during activation, we investigated the functional significance of PD-L1 expressed by donor T cells in regulating murine models of acute GVHD. PD-L1 expression was up-regulated on donor CD4 and CD8 T cells during GVHD. We considered the possibility that PD-...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 375.2KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 699.7KB, Terms of use)
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Authors
- Publisher:
- American Society of Hematology
- Host title:
- Blood
- Journal:
- Blood More from this journal
- Volume:
- 126
- Issue:
- 23
- Pages:
- 147
- Publication date:
- 2015-12-03
- EISSN:
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1528-0020
- ISSN:
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0006-4971
- Keywords:
- Pubs id:
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pubs:611135
- UUID:
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uuid:ef8ed5b2-e323-46a5-b920-78a824deb0f4
- Local pid:
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pubs:611135
- Source identifiers:
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611135
- Deposit date:
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2017-01-03
- ARK identifier:
Terms of use
- Copyright holder:
- The American Society of Hematology
- Copyright date:
- 2015
- Notes:
- © 2015 by The American Society of Hematology
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