Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study

Abbas, S; Linseisen, J; Rohrmann, S; Beulens, J; Buijsse, B; Amiano, P; Ardanaz, E; Balkau, B; Boeing, H; Clavel-Chapelon, F; Fagherazzi, G; Franks, P; Gavrila, D; Grioni, S; Kaaks, R; Key, T; Khaw, K; Kühn, T; Mattiello, A; Molina-Montes, E; Nilsson, P; Overvad, K; Quirós, JR; Rolandsson, O; Sacerdote, C

Journal article

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study

Abstract:: Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

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APA Style

Abbas, S., Linseisen, J., Rohrmann, S., Beulens, J., Buijsse, B., Amiano, P., Ardanaz, E., Balkau, B., Boeing, H., Clavel-Chapelon, F., Fagherazzi, G., Franks, P., Gavrila, D., Grioni, S., Kaaks, R., Key, T., Khaw, K., Kühn, T., Mattiello, A., … Sacerdote, C. (2014). Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study. European Journal of Clinical Nutrition, 68(2), 196–202.

MLA Style

Abbas, S, et al. “Dietary Vitamin D Intake and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct Study.” European Journal of Clinical Nutrition, vol. 68, no. 2, 2014, pp. 196–202.

Chicago Style

Abbas, S, J Linseisen, S Rohrmann, et al. 2014. “Dietary Vitamin D Intake and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct Study.” European Journal of Clinical Nutrition 68 (2): 196–202.
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