Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia.

Journal article

BACKGROUND: 5-HT2A receptor is strongly implicated in the mode of action of atypical antipsychotic drugs. The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia. METHODS: We studied 99 Caucasian schizophrenia patients treated with olanzapine. Psychopathology was measured before and after 6 weeks of treatment. Clinical improvement was quantified as change in P...

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Authors: Olajossy-Hilkesberger, L; Godlewska, B; Schosser-Haupt, A; Olajossy, M; Wojcierowski, J

• Journal: Neuropsychobiology
• Volume: 64
• Issue: 4
• Pages: 202-210
• Publication date: 2011-01-01
• DOI: 10.1159/000327602
• EISSN: 1423-0224
• ISSN: 0302-282X
• Language: English
• Keywords: Psychiatric Status Rating Scales; Female; Humans; Receptor, Serotonin, 5-HT2A; Antipsychotic Agents; Genotype; Gene Frequency; Benzodiazepines; Middle Aged; Adult; Male; Aged; Schizophrenia, Paranoid; Adolescent; Polymorphism, Single Nucleotide; Sex Characteristics