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Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia.

Abstract:

BACKGROUND: 5-HT2A receptor is strongly implicated in the mode of action of atypical antipsychotic drugs. The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia. METHODS: We studied 99 Caucasian schizophrenia patients treated with olanzapine. Psychopathology was measured before and after 6 weeks of treatment. Clinical improvement was quantified as change in P...

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Publisher copy:
10.1159/000327602

Authors


Olajossy-Hilkesberger, L More by this author
Godlewska, B More by this author
Schosser-Haupt, A More by this author
Olajossy, M More by this author
Wojcierowski, J More by this author
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Journal:
Neuropsychobiology
Volume:
64
Issue:
4
Pages:
202-210
Publication date:
2011
DOI:
EISSN:
1423-0224
ISSN:
0302-282X
URN:
uuid:ef7ad317-0550-447c-bfdb-bd59eec7cb95
Source identifiers:
355525
Local pid:
pubs:355525

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