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Alterations in the phenotype of hairy cells during culture in the presence of PHA: requirement for T cells.

Abstract:

Culture studies of peripheral blood mononuclear cells from 7 entirely typical cases of hairy cell leukemia showed that after culture in the presence of PHA for 2--5 days, the predominant cell type changed from E- SIg+ CIg+ gamma FcR+ muFcR+ hairy cells to an E+ SIg- CIg- gamma FcR-muFcR- population of transformed cells derived from hairy cells. Depletion and readdition experiments demonstrated that cell-to-cell contact with T cells was necessary for the phenotypic change, while several observ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Blood
Volume:
59
Issue:
5
Pages:
895-899
Publication date:
1982-05-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:ef792cdb-3d57-44b1-adb8-fe81c0582ed2
Source identifiers:
35554
Local pid:
pubs:35554

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