Journal article icon

Journal article

System-wide profiling of RNA-binding proteins uncovers key regulators of virus infection

Abstract:

The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the development of RNA interactome capture (RIC). However, it remained unknown if the complement of RBPs changes in response to environmental perturbations and whether these rearrangements are important. To answer these questions, we developed ‘comparative RIC’ and applied it to cells challenged with an RNA virus, called sindbis (SINV). Over two hundred RBPs display differential interaction with RNA upon SINV infection...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.molcel.2019.01.017

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
74
Issue:
1
Pages:
196-211.e11
Publication date:
2019-02-21
Acceptance date:
2019-01-11
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pubs id:
pubs:959482
URN:
uri:ef74ca9d-1146-47ed-904c-93f588b9fb1d
UUID:
uuid:ef74ca9d-1146-47ed-904c-93f588b9fb1d
Local pid:
pubs:959482

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP