Journal article
PCSK6 is associated with handedness in individuals with dyslexia.
- Abstract:
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Approximately 90% of humans are right-handed. Handedness is a heritable trait, yet the genetic basis is not well understood. Here we report a genome-wide association study for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)]. The most highly associated marker, rs11855415 (P = 4.7 × 10(-7)), is located within PCSK6. Two independent cohorts with RD show the same trend, with the minor allele conferring greater relative right-hand skill. Meta-an...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 145.7KB, Terms of use)
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- Publisher copy:
- 10.1093/hmg/ddq475
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Funding
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Human molecular genetics More from this journal
- Volume:
- 20
- Issue:
- 3
- Pages:
- 608-614
- Publication date:
- 2011-02-01
- DOI:
- EISSN:
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1460-2083
- ISSN:
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0964-6906
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:ef70568e-02b3-45fb-bfb9-9b7e2d10e5b2
- Local pid:
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pubs:93197
- Source identifiers:
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93197
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Scerri et al
- Copyright date:
- 2011
- Notes:
- Copyright © 2010 Scerri et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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