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Influenza virus-specific cytotoxic T lymphocytes recognize HLA-molecules. Blocking by monoclonal anti-HLA antibodies.

Abstract:

The effect of monoclonal anti-HLA antibodies on lysis of influenza virus-infected target cells by sensitized cytotoxic T lymphocytes was measured. Lysis was blocked, provided the antibody was present in a concentration sufficient to saturate the HLA determinants on the target cells. Antibodies to monomorphic HLA determinants and to beta 2-microglobulin inhibited. Antibody to HLA A2 and B17 blocked lysis of target cells that shared these antigens with the effector cell. It was concluded that t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
152
Issue:
2 Pt 2
Pages:
195s-203s
Publication date:
1980-08-05
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ef6fa409-1c0d-4067-85a3-daf0805f7cf3
Source identifiers:
41901
Local pid:
pubs:41901

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