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Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.

Abstract:

T-cell production throughout life depends on efficient colonization and intrathymic expansion of BM-derived hematopoietic precursors. After irradiation-induced thymic damage, thymic recovery is facilitated by Flt3 ligand (FL), expressed by perivascular fibroblasts surrounding the thymic entry site of Flt3 receptor-positive progenitor cells. Whether intrathymic FL-Flt3 interactions play a role in steady-state replenishment of T cells remains unknown. Here, using competitive BM transplantation ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200839213

Authors


Journal:
European journal of immunology
Volume:
40
Issue:
1
Pages:
81-90
Publication date:
2010-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:ef68bc94-b7ed-4188-8059-eaa5eaa8e323
Source identifiers:
309045
Local pid:
pubs:309045

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