Nifedipine in rat liver cirrhosis.

Journal article

Rat liver cirrhosis induced by CCl4+ethanol was employed to assess the effectiveness of nifedipine in reducing liver injury. Nifedipine reduced the severity of hepatocellular necrosis, significantly decreased Mallory bodies (p < 0.01), decreased polymorphonuclear inflammatory infiltrate (p < 0.05) and reduced perivenular fibrosis. Plasma lactic acid levels were significantly increased in the CCl4+ethanol group (p < 0.01). Lactacidaemia remained at normal values when the calcium antagonist blocker was employed. Nifedipine did not significantly alter the incidence of cirrhosis in this experimental model.

Authors: Cutrin, C; Menino, J; Carballo, C; Parafita, M; Perez-Becerra, E

• Journal: Veterinary and human toxicology
• Volume: 36
• Issue: 1
• Pages: 14-16
• Publication date: 1994-02-01
• ISSN: 0145-6296
• Language: English
• Keywords: Nifedipine; Rats; Liver Cirrhosis, Experimental; Male; Ethanol; Animals; Rats, Wistar; Carbon Tetrachloride; Lactates; Liver; Lactic Acid; Liver Function Tests