Paracheck-Pf: a new, inexpensive and reliable rapid test for P. falciparum malaria.

Journal article

We compared the performance of Paracheck-Pf, a new and cheap rapid malaria test, with ICT-Pf/PvR and microscopy in two malaria surveys in Thai villages on the Thai-Burmese border. The specificity, sensitivity, predictive positive and negative values of the Paracheck-PfR and ICT-PfR tests were calculated taking microscopy results as the gold standard. The 294 ICT-Pf/Pv tests resulted in two invalid (no control line) and 11 doubtful results. Both the ICT-Pf/PvR and Paracheck-PfR tests reliably detected P. falciparum infections. However, Paracheck-PfR failed to detect three P. falciparum cases and likewise, ICT-Pf/PvR failed to detect the same three cases and an additional four cases. These seven cases were detected by microscopy and had a parasitaemia under 150 parasites/microl. At a cost of c. US $1.00, the Paracheck-PfR test, based on the detection of the P. falciparum specific HRP-2 protein, is a reliable, easy to use and affordable tool for the diagnosis of P. falciparum malaria.

Authors: Proux, S; Hkirijareon, L; Ngamngonkiri, C; McConnell, S; Nosten, F

• Publication status: Published
• Journal: Tropical medicine and international health : TM and IH
• Volume: 6
• Issue: 2
• Pages: 99-101
• Publication date: 2001-02-01
• DOI: 10.1046/j.1365-3156.2001.00694.x
• EISSN: 1365-3156
• ISSN: 1360-2276
• Language: English
• Keywords: Sensitivity and Specificity; Proteins; Cross-Sectional Studies; Mass Screening; Drug Resistance; Rural Health; Health Surveys; Animals; Microscopy; Thailand; Time Factors; Malaria, Falciparum; Predictive Value of Tests; Plasmodium falciparum; Humans