Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.

Journal article

This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 and characterizes the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains. For 1,393 serovar Typhi strains collected in southern Vietnam, the proportion of multidrug resistance has remained high since 1993 (50% in 2004) and there was a dramatic increase in nalidixic acid resistance between ...

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Authors: Chau, T; Campbell, J; Galindo, C; Van Minh Hoang, N; Diep, T

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 51
• Issue: 12
• Pages: 4315-4323
• Publication date: 2007-12-01
• DOI: 10.1128/aac.00294-07
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Vietnam; Asia; India; Anti-Bacterial Agents; DNA Mutational Analysis; Humans; Drug Resistance, Microbial; Microbial Sensitivity Tests; Mutation; Bangladesh; DNA Gyrase; Indonesia; Nepal; Salmonella typhi; Pakistan; Laos; Fluoroquinolones; DNA Topoisomerase IV; China