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A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH.

Abstract:

We analysed chromosome 16q in 106 breast cancers using tiling-path array-comparative genomic hybridization (aCGH). About 80% of ductal cancers (IDCs) and all lobular cancers (ILCs) lost at least part of 16q. Grade I (GI) IDCs and ILCs often lost the whole chromosome arm. Grade II (GII) and grade III (GIII) IDCs showed less frequent whole-arm loss, but often had complex changes, typically small regions of gain together with larger regions of loss. The boundaries of gains/losses tended to clust...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1209659

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Journal:
Oncogene
Volume:
25
Issue:
49
Pages:
6544-6553
Publication date:
2006-10-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:ef4cbfbf-c794-4275-8cd4-53d23fde6023
Source identifiers:
72048
Local pid:
pubs:72048

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