Journal article
The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.
- Abstract:
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BACKGROUND: Lumefantrine and atovaquone are highly lipophilic anti-malarial drugs. As a consequence absorption is increased when the drugs are taken together with a fatty meal, but the free fraction of active drug decreases in the presence of triglyceride-rich plasma lipoproteins. In this study, the consequences of lipidaemia on anti-malarial drug efficacy were assessed in vitro. METHODS: Serum was obtained from non-immune volunteers under fasting conditions and after ingestion of a high fat ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 247.6KB, Terms of use)
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- Publisher copy:
- 10.1186/1475-2875-11-177
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Funding
Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- Malaria journal More from this journal
- Volume:
- 11
- Issue:
- 1
- Article number:
- 177
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1475-2875
- ISSN:
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1475-2875
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:ef452625-83a5-4271-908d-985f8fc17967
- Local pid:
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pubs:334766
- Source identifiers:
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334766
- Deposit date:
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2013-11-16
Terms of use
- Copyright holder:
- Chotivanich et al
- Copyright date:
- 2012
- Notes:
- © 2012 Chotivanich et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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