Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder.

Journal article

CONTEXT: Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified. OBJECTIVES: To investigate structural brain changes in MDD using meta-analysis of primary studies; assess the effects of medication, demographic, and clinical variables; and compare the findings with those of a meta-analysis of studies on BD. DATA SOURCES: The MEDLI...

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Authors: Kempton, M; Salvador, Z; Munafò, MR; Geddes, J; Simmons, A

• Publication status: Published
• Journal: Archives of general psychiatry
• Volume: 68
• Issue: 7
• Pages: 675-690
• Publication date: 2011-07-01
• DOI: 10.1001/archgenpsychiatry.2011.60
• EISSN: 1538-3636
• ISSN: 0003-990X
• Language: English
• Keywords: Bipolar Disorder; Thalamus; Basal Ganglia; Depressive Disorder, Major; Brain; Humans; Organ Size; Magnetic Resonance Imaging; Hippocampus; Frontal Lobe; Male; Tomography, X-Ray Computed; Female; Middle Aged