Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.

Isaacs, JD; Clark, MR; Greenwood, J; Waldmann, H

Abstract:

A set of rat-human and rat-rat chimeric mAb has been created, all possessing V regions identical in their specificity for the mouse CD8 Ag. In vitro all antibodies were able to block cell-mediated lysis but varied greatly in their capacity to utilize rabbit complement. We examined the ability of these chimeric antibodies to deplete in vivo and established a clear hierarchy. Of the human IgG subclasses, only IgG1, 2, and 3 could fix complement in vitro, yet all (IgG1-4) were remarkably potent ...

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APA Style

Isaacs, J. D., Clark, M. R., Greenwood, J., & Waldmann, H. (1992). Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential. Journal of Immunology (Baltimore, Md. : 1950), 148(10), 3062–3071.

MLA Style

Isaacs, J. D., et al. “Therapy with Monoclonal Antibodies. An in Vivo Model for the Assessment of Therapeutic Potential.” Journal of Immunology (Baltimore, Md. : 1950), vol. 148, no. 10, 1992, pp. 3062–71.

Chicago Style

Isaacs, JD, MR Clark, J Greenwood, and H Waldmann. 1992. “Therapy with Monoclonal Antibodies. An in Vivo Model for the Assessment of Therapeutic Potential.” Journal of Immunology (Baltimore, Md. : 1950) 148 (10): 3062–71.
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