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Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.

Abstract:

A set of rat-human and rat-rat chimeric mAb has been created, all possessing V regions identical in their specificity for the mouse CD8 Ag. In vitro all antibodies were able to block cell-mediated lysis but varied greatly in their capacity to utilize rabbit complement. We examined the ability of these chimeric antibodies to deplete in vivo and established a clear hierarchy. Of the human IgG subclasses, only IgG1, 2, and 3 could fix complement in vitro, yet all (IgG1-4) were remarkably potent ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
148
Issue:
10
Pages:
3062-3071
Publication date:
1992-05-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:ef3c61a5-fa71-4231-a30c-58aaff701826
Source identifiers:
9072
Local pid:
pubs:9072

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