Journal article
Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential.
- Abstract:
-
A set of rat-human and rat-rat chimeric mAb has been created, all possessing V regions identical in their specificity for the mouse CD8 Ag. In vitro all antibodies were able to block cell-mediated lysis but varied greatly in their capacity to utilize rabbit complement. We examined the ability of these chimeric antibodies to deplete in vivo and established a clear hierarchy. Of the human IgG subclasses, only IgG1, 2, and 3 could fix complement in vitro, yet all (IgG1-4) were remarkably potent ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 148
- Issue:
- 10
- Pages:
- 3062-3071
- Publication date:
- 1992-05-01
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
9072
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:9072
- UUID:
-
uuid:ef3c61a5-fa71-4231-a30c-58aaff701826
- Local pid:
- pubs:9072
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1992
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