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Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat.

Abstract:

Rats were trained to lever press on a differential reinforcement of low rates (DRL-18 s) schedule. They were then allocated to four treatment groups. These were: hippocampal aspiration lesions [HIPP]; implantation of osmotic minipumps for intraventricular infusion of either (a) the NMDA receptor antagonist 30 mM D, L-2-amino-5-phosphonopentanoic acid [AP5] or (b) vehicle [VEH]; and an unoperated control group [UNOP]. In subsequent DRL testing, the HIPP group showed a profound and enduring los...

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Publication status:
Published

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Publisher copy:
10.1007/bf00279671

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Experimental brain research
Volume:
73
Issue:
1
Pages:
181-188
Publication date:
1988-01-01
DOI:
EISSN:
1432-1106
ISSN:
0014-4819
URN:
uuid:ef3c5ba6-ba05-41b6-807c-be39631b4b14
Source identifiers:
3021
Local pid:
pubs:3021

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