Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat.

Journal article

Rats were trained to lever press on a differential reinforcement of low rates (DRL-18 s) schedule. They were then allocated to four treatment groups. These were: hippocampal aspiration lesions [HIPP]; implantation of osmotic minipumps for intraventricular infusion of either (a) the NMDA receptor antagonist 30 mM D, L-2-amino-5-phosphonopentanoic acid [AP5] or (b) vehicle [VEH]; and an unoperated control group [UNOP]. In subsequent DRL testing, the HIPP group showed a profound and enduring los...

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Authors: Tonkiss, J; Morris, R; Rawlins, J

• Publication status: Published
• Journal: Experimental brain research
• Volume: 73
• Issue: 1
• Pages: 181-188
• Publication date: 1988-01-01
• DOI: 10.1007/bf00279671
• EISSN: 1432-1106
• ISSN: 0014-4819
• Language: English
• Keywords: Animals; Injections, Intraventricular; Male; Receptors, Neurotransmitter; Rats; Rats, Inbred Strains; 2-Amino-5-phosphonovalerate; Memory; Retention (Psychology); Valine; Receptors, N-Methyl-D-Aspartate; Reinforcement (Psychology); Hippocampus