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Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group.

Abstract:

Genome-wide association (GWA) studies have proved extremely successful in identifying novel genetic loci contributing effects to complex human diseases. In doing so, they have highlighted the fact that many potential loci of modest effect remain undetected, partly due to the need for samples consisting of many thousands of individuals. Large-scale international initiatives, such as the Wellcome Trust Case Control Consortium, the Genetic Association Information Network, and the database of gen...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20482

Authors


Zhuang, JJ More by this author
Zondervan, K More by this author
Harbron, C More by this author
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Volume:
34
Issue:
4
Pages:
319-326
Publication date:
2010-05-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:ef3b45bf-a059-4185-a629-778b4dd10f3d
Source identifiers:
40960
Local pid:
pubs:40960

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