Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders.

Journal article

OBJECTIVES: To analyze aquaporin-4 (AQP4) antibody-positive patients who do not fulfill the current diagnostic criteria of neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD). METHODS: We used a cell-based assay (CBA) with AQP4-transfected cells to detect AQP4 antibody in 298 consecutive patients with inflammatory CNS disorders seen at Tohoku University Hospital from 2007 to 2012. The patients were diagnosed as NMO, NMOSD, multiple sclerosis, or others using the respective current ...

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Authors: Sato, D; Nakashima, I; Takahashi, T; Misu, T; Waters, P

• Publication status: Published
• Journal: Neurology
• Volume: 80
• Issue: 24
• Pages: 2210-2216
• Publication date: 2013-06-01
• DOI: 10.1212/wnl.0b013e318296ea08
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: HEK293 Cells; Biological Markers; Autoantibodies; Follow-Up Studies; Aged; Humans; Adult; Female; Male; Cross-Sectional Studies; Aquaporin 4; Neuromyelitis Optica; Enzyme-Linked Immunosorbent Assay; Middle Aged