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Journal article

Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.

Abstract:

The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surprisingly, VLPs were not transported from the lung to the spleen in a free form but by B cells. The interaction between VLPs and B cells was initiated in the lung and occurred independently of compleme...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1206970109

Authors


Jegerlehner, A More by this author
Hinton, HJ More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
50
Pages:
20566-20571
Publication date:
2012-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ef34fb2a-47d4-4c76-8839-bd064148908e
Source identifiers:
422262
Local pid:
pubs:422262

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