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Thesis

Interactions between myofibroblasts and colorectal cancer (CRC) epithelial cell lines

Abstract:

Myofibroblasts are an important cellular component of the tumour microenvironment and play an essential role in facilitating carcinogenesis through bidirectional communications with epithelial cells. Accumulation of myofibroblasts is associated with poor prognosis in colorectal cancers. Myofibroblasts are distinguished from skin fibroblasts by positive expression of amine oxidase, copper containing 3 (AOC3) and NKX2-3. The current project aims to study the in vitro interactions between myo...

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Department:
Cancer Immunogenetic Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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