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Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.

Abstract:

BACKGROUND: Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited. METHODS: In an open-label, controlled, multicenter trial, we randomly assigned 708 patients with a suboptimal glycated hemoglobin level (7.0 to 10.0%) who were receiving maximally tolerated doses of metformin and sulfonylurea to receive biphasic insulin aspart twice daily, prandial insulin aspart three times ...

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Publication status:
Published

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Publisher copy:
10.1056/nejmoa075392

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Thorne, KI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, Biomedical RC
Davies, MJ More by this author
Keenan, JF More by this author
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Journal:
The New England journal of medicine
Volume:
357
Issue:
17
Pages:
1716-1730
Publication date:
2007-10-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:ef333535-6d4d-4f17-bbf1-da2ec4098233
Source identifiers:
29054
Local pid:
pubs:29054

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