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Journal article

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.

Abstract:

Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the widespread autoimmunity of Aire-deficient individuals reflects a lack of tolerance induction to the repertoire of peripheral tissue antigens expressed in the thymus of normal individuals. Here, we su...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0700259104

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
11
Pages:
4583-4587
Publication date:
2007-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ef316a40-1222-41e7-91e9-6e31e99bd0ff
Source identifiers:
5677
Local pid:
pubs:5677

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