HIV infection and its association with an excess risk of clinical fractures: a nationwide case-control study.

Journal article

BACKGROUND: Different studies have reported an association between HIV infection, antiretroviral therapies, and impaired bone metabolism, but data on their impact on fracture risk are scarce. We studied the association between a clinical diagnosis of HIV infection and fracture risk. METHODS: We conducted a case-control study using data from the Danish National Health Service registries, including 124,655 fracture cases and 373,962 age- and gender-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. RESULTS: A total of 50 (0.40/1000) patients in the fracture group and 52 (0.14/1000) controls had an HIV diagnosis. The risk of any fracture was thus significantly increased among HIV-infected patients (age- and gender-matched OR = 2.89, 95% CI: 1.99 to 4.18). Similarly, significant increases in the risk of hip (OR = 8.99, 95% CI: 1.39 to 58.0), forearm (OR = 3.50, 95% CI: 1.26 to 9.72), and spine fractures (OR = 9.00, 95% CI: 1.39 to 58.1) were observed. CONCLUSIONS: HIV infection is associated with an almost 3-fold increase in fracture risk compared with that of age- and gender-matched uninfected patients. HIV patients are also at an almost 9-fold higher risk of hip fracture.

Authors: Prieto-Alhambra, D; Güerri-Fernández, R; De Vries, F; Lalmohamed, A; Bazelier, M

• Publication status: Published
• Publisher: Lippincott Williams and Wilkins
• Journal: Journal of acquired immune deficiency syndromes (1999)
• Volume: 66
• Issue: 1
• Pages: 90-95
• Publication date: 2014-05-01
• DOI: 10.1097/qai.0000000000000112
• EISSN: 1944-7884
• ISSN: 1525-4135
• Language: English
• Keywords: HIV Infections; Humans; Male; Aged, 80 and over; Infant, Newborn; Aged; Middle Aged; Case-Control Studies; Risk Assessment; Fractures, Bone; Child; Denmark; Infant; Female; Young Adult; Adolescent; Adult; Child, Preschool