Modelling carcinogenesis after radiotherapy using Poisson statistics: implications for IMRT, protons and ions.

Journal article

Current technical radiotherapy advances aim to (a) better conform the dose contours to cancers and (b) reduce the integral dose exposure and thereby minimise unnecessary dose exposure to normal tissues unaffected by the cancer. Various types of conformal and intensity modulated radiotherapy (IMRT) using x-rays can achieve (a) while charged particle therapy (CPT)-using proton and ion beams-can achieve both (a) and (b), but at greater financial cost. Not only is the long term risk of radiation ...

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Authors: Jones, B

• Publication status: Published
• Journal: Journal of radiological protection : official journal of the Society for Radiological Protection
• Volume: 29
• Issue: 2A
• Pages: A143-A157
• Publication date: 2009-06-01
• DOI: 10.1088/0952-4746/29/2a/s10
• EISSN: 1361-6498
• ISSN: 0952-4746
• Language: English
• Keywords: Neoplasms, Radiation-Induced; Protons; Heavy Ions; Relative Biological Effectiveness; Linear Energy Transfer; DNA Repair; Poisson Distribution; Radiation Dosage; Radiotherapy, Intensity-Modulated; Models, Biological