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Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia.

Abstract:

We aimed to elucidate the effect of hyperhomocysteinemia (HHcy) on the synthesis of prostaglandins in rat skeletal muscle arterioles and platelets. Male Wistar rats were divided into 2 groups: (1) control rats, with plasma Hcy levels of 6.5+/-0.5 micromol/L (n=50) and (2) rats with HHcy, induced by daily intake of 1 g/kg body weight methionine in the drinking water for 4 weeks (plasma Hcy levels were 20.6+/-3.0 micromol/L, P<0.01 versus controls; n=50). Arterioles (diameter approximately 1...

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Publication status:
Published

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Publisher copy:
10.1161/01.atv.20.5.1203

Authors


Ungvari, Z More by this author
Sarkadi-Nagy, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Szollár, L More by this author
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
20
Issue:
5
Pages:
1203-1208
Publication date:
2000-05-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:ef18c922-03e0-4e84-8af8-346268e4cf16
Source identifiers:
164525
Local pid:
pubs:164525

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