Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia.

Journal article

We aimed to elucidate the effect of hyperhomocysteinemia (HHcy) on the synthesis of prostaglandins in rat skeletal muscle arterioles and platelets. Male Wistar rats were divided into 2 groups: (1) control rats, with plasma Hcy levels of 6.5+/-0.5 micromol/L (n=50) and (2) rats with HHcy, induced by daily intake of 1 g/kg body weight methionine in the drinking water for 4 weeks (plasma Hcy levels were 20.6+/-3.0 micromol/L, P<0.01 versus controls; n=50). Arterioles (diameter approximately 1...

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Authors: Ungvari, Z; Sarkadi-Nagy, E; Bagi, Z; Szollár, L; Koller, A

• Publication status: Published
• Journal: Arteriosclerosis, thrombosis, and vascular biology
• Volume: 20
• Issue: 5
• Pages: 1203-1208
• Publication date: 2000-05-01
• DOI: 10.1161/01.atv.20.5.1203
• EISSN: 1524-4636
• ISSN: 1079-5642
• Language: English
• Keywords: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Blood Pressure; Animals; Rats, Wistar; Platelet Aggregation; Rats; Male; Vasoconstriction; Arterioles; Blood Platelets; Vasoconstrictor Agents; Collagen; Bradykinin; Lipid Peroxidation; Hyperhomocysteinemia; Fatty Acids; Thromboxane A2