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Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice.

Abstract:

BACKGROUND: In the current study, we have investigated whether low density lipoprotein receptor knockout mice (LDLR-KO), moderate oxidative stress model and cholesteremia burden display gastroparesis and if so whether nitrergic system is involved in this setting. In addition, we have investigated if sepiapterin (SEP) supplementation attenuated impaired nitrergic system and delayed gastric emptying. METHODS: Gastric emptying and nitrergic relaxation were measured in overnight fasting mice. nNO...

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Publication status:
Published

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Authors


Gangula, PR More by this author
Chinnathambi, V More by this author
Mukhopadhyay, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Journal:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Volume:
23
Issue:
8
Pages:
773-e335
Publication date:
2011-08-05
DOI:
EISSN:
1365-2982
ISSN:
1350-1925
URN:
uuid:ef125f92-41de-4002-8ceb-4a87dde7a394
Source identifiers:
127151
Local pid:
pubs:127151

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