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Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging.

Abstract:

We have characterized the biodistribution and dosimetry of (18)F-3'-F-6-OH-BTA1 ((18)F-GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy elderly human subjects.Six subjects (5 men and 1 woman; age range, 51-74 y) underwent dynamic whole-body PET/CT for 6 h after a bolus injection of (18)F-GE067. Source organs were delineated on PET/CT. Individual organ doses and effective doses were determined.No adverse events or clinically significant changes were ob...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.108.060756

Authors


Buckley, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Vandenbulcke, M More by this author
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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
50
Issue:
5
Pages:
818-822
Publication date:
2009-05-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:ef0307fb-db65-4d40-8010-82ee066e2088
Source identifiers:
429456
Local pid:
pubs:429456

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