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Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells.

Abstract:

BACKGROUND: The aim was to analyze the influence of intestinal microbiota on the development of intestinal inflammation. We used the model of chronic inflammation that develops spontaneously in the colon of conventional severe combined immunodeficiency (SCID) mice restored with the CD45 RB(high) subset of CD4+T cells isolated from the spleen of normal BALB/c mice. METHODS: A CD4+CD45RB(high) subpopulation of T cells was purified from the spleen of conventional BALB/c mice by magnetic separat...

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Publication status:
Published

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Publisher copy:
10.1002/ibd.20221

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Journal:
Inflammatory bowel diseases
Volume:
13
Issue:
10
Pages:
1202-1211
Publication date:
2007-10-05
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
URN:
uuid:eef21beb-7355-4dd1-bca2-4eb60dcd2f2a
Source identifiers:
27864
Local pid:
pubs:27864

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