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Enzyme kinetics at high enzyme concentration.

Abstract:

We re-visit previous analyses of the classical Michaelis-Menten substrate-enzyme reaction and, with the aid of the reverse quasi-steady-state assumption, we challenge the approximation d[C]/dt approximately 0 for the basic enzyme reaction at high enzyme concentration. For the first time, an approximate solution for the concentrations of the reactants uniformly valid in time is reported. Numerical simulations are presented to verify this solution. We show that an analytical approximation can b...

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Publication status:
Published

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Publisher copy:
10.1006/bulm.1999.0163

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Bulletin of mathematical biology
Volume:
62
Issue:
3
Pages:
483-499
Publication date:
2000-05-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:eef0ecf6-b0ee-4d24-9d7c-b9742f37ea87
Source identifiers:
25479
Local pid:
pubs:25479

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