Journal article

Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study

Abstract:: Background
Analysis of circulating tumour DNA could stratify cancer risk in symptomatic patients. We aimed to evaluate the performance of a methylation-based multicancer early detection (MCED) diagnostic test in symptomatic patients referred from primary care.
Methods
We did a multicentre, prospective, observational study at National Health Service (NHS) hospital sites in England and Wales. Participants aged 18 or older referred with non-specific symptoms or sym... Expand abstract
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Nicholson, B. D., Oke, J., Virdee, P. S., Harris, D. A., O'Doherty, C., Park, J. E. S., Hamady, Z., Sehgal, V., Millar, A., Medley, L., Tonner, S., Vargova, M., Engonidou, L., Riahi, K., Luan, Y., Hiom, S., Kumar, H., Nandani, H., Kurtzman, K. N., … Middleton, M. R. (2023). Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study. Lancet Oncology, 24(7), 733–743.

MLA Style

Nicholson, BD, et al. “Multi-Cancer Early Detection Test in Symptomatic Patients Referred for Cancer Investigation in England and Wales (SYMPLIFY): a Large-Scale, Observational Cohort Study.” Lancet Oncology, vol. 24, no. 7, 2023, pp. 733–43.

Chicago Style

Nicholson, BD, J Oke, PS Virdee, et al. 2023. “Multi-Cancer Early Detection Test in Symptomatic Patients Referred for Cancer Investigation in England and Wales (SYMPLIFY): a Large-Scale, Observational Cohort Study.” Lancet Oncology 24 (7): 733–43.
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Files:: Nicholson_et_al_2023_Multi-cancer_early_detection.pdf

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Publisher copy:: 10.1016/s1470-2045(23)00277-2

Authors

+ Nicholson, BD More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Primary Care Health Sciences
Role:: Author
ORCID:: 0000-0003-0661-7362

+ Oke, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Primary Care Health Sciences
Role:: Author

+ Virdee, PS More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Primary Care Health Sciences
Role:: Author
ORCID:: 0000-0002-3006-8730

+ Harris, DA More by this author

Role:: Author

+ O'Doherty, C More by this author

Role:: Author

More authors...

+ National Institute for Health Research More from this funder

Funder identifier:: https://ror.org/0187kwz08
Grant:: CL-2019-13-005

Publisher:: Elsevier
Journal:: Lancet Oncology More from this journal
Volume:: 24
Issue:: 7
Pages:: 733-743
Place of publication:: England
Publication date:: 2023-06-20
DOI:: 10.1016/s1470-2045(23)00277-2
EISSN:: 1474-5488
ISSN:: 1470-2045
Pmid:: 37352875

Language:: English
Pubs id:: 1488799
Local pid:: pubs:1488799
Deposit date:: 2024-04-16
ARK identifier:: ark:/29072/ora_eeec8c992e6d410e96d159d222886afc

Terms of use

Copyright holder:: Nicholson et al.
Copyright date:: 2023
Rights statement:: © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Licence:: CC Attribution (CC BY)

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