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Journal article

Coating of adenovirus type 5 with polymers containing quaternary amines prevents binding to blood components.

Abstract:

Adenovirus type 5 (Ad5) gene therapy vectors require protection against antibodies, complement proteins and blood cells if they are to be delivered intravenously to treat metastatic disease. Such protection can be achieved by chemically modifying Ad5 with polymers based on hydrophilic HPMA. Here, such polymers were designed to include side chains bearing reactive carbonyl thiazolidine-2-thione groups (TTs) to covalently modify available amino groups of the lysine residues in the Ad5 capsid. F...

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Publication status:
Published

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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
135
Issue:
2
Pages:
152-158
Publication date:
2009-04-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:eeec238b-c292-4417-adf4-713f8f55a050
Source identifiers:
178801
Local pid:
pubs:178801

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