Journal article
Retinal changes in visceral leishmaniasis by retinal photography
- Abstract:
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Background: In visceral leishmaniasis (VL), retinal changes have previously been noted but not described in detail and their clinical and pathological significance are unknown. A prospective observational study was undertaken in Mymensingh, Bangladesh aiming to describe in detail visible changes in the retina in unselected patients with VL.
Methods: Patients underwent assessment of visual function, indirect and direct ophthalmoscopy and portable retinal photography. The photographs were assessed by masked observers including assessment for vessel tortuosity using a semi-automated system.
Results: 30 patients with VL were enrolled, of whom 6 (20%) had abnormalities. These included 5 with focal retinal whitening, 2 with cotton wool spots, 2 with haemorrhages, as well as increased vessel tortuosity. Visual function was preserved.
Conclusions: These changes suggest a previously unrecognized retinal vasculopathy. An inflammatory aetiology is plausible such as a subclinical retinal vasculitis, possibly with altered local microvascular autoregulation, and warrants further investigation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 288.8KB, Terms of use)
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- Publisher copy:
- 10.1186/1471-2334-14-527
Authors
- Publisher:
- BioMed Central
- Journal:
- BMC Infectious Diseases More from this journal
- Volume:
- 14
- Article number:
- 527
- Publication date:
- 2014-09-30
- Acceptance date:
- 2014-09-23
- DOI:
- EISSN:
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1471-2334
- Language:
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English
- Keywords:
- Pubs id:
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485979
- UUID:
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uuid:eee7a83b-1a85-429d-a3b4-ecc14ba2c4ab
- Local pid:
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pubs:485979
- Source identifiers:
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485979
- Deposit date:
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2014-11-18
- ARK identifier:
Terms of use
- Copyright holder:
- Maude et al
- Copyright date:
- 2014
- Notes:
- © 2014 Maude et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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