Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.

Journal article

OBJECTIVE: To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. DESIGN: Retrospective study. SETTING: Fertility centers. PATIENT(S): Infertile couples undergoing IVF. INTERVENTION(S): Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year. MAIN OUTCOME MEASURE(S): Meiosis I aneuploidy. RESULT(S): A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles. CONCLUSION(S): Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.

Authors: Munné, S; Held, K; Magli, C; Ata, B; Wells, D

• Publication status: Published
• Journal: Fertility and sterility
• Volume: 97
• Issue: 4
• Pages: 935-942
• Publication date: 2012-04-01
• DOI: 10.1016/j.fertnstert.2012.01.106
• EISSN: 1556-5653
• ISSN: 0015-0282
• Language: English
• Keywords: Meiosis; Linear Models; Health Facilities; Adult; Preimplantation Diagnosis; Ovulation; Risk Factors; Cryopreservation; Polar Bodies; Oocytes; Infertility; Biopsy; In Situ Hybridization, Fluorescence; Chromosome Aberrations; Female; Italy; Middle Aged; Time Factors; Aneuploidy; Ovulation Induction; Risk Assessment; Germany; Retrospective Studies; Age Factors; Humans; Genetic Testing; Fertility Agents, Female; Chromosomes, Human