Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression.

Journal article

The controls that enable melanoblasts and melanoma cells to proliferate are likely to be related, but so far no key regulator of cell cycle progression specific to the melanocyte lineage has been identified. The microphthalmia-associated transcription factor Mitf has a crucial but poorly defined role in melanoblast and melanocyte survival and in differentiation. Here we show that Mitf can act as a novel anti-proliferative transcription factor able to induce a G1 cell-cycle arrest that is depe...

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Authors: Carreira, S; Goodall, J; Aksan, I; La Rocca, SA; Galibert, MD

• Publication status: Published
• Journal: Nature
• Volume: 433
• Issue: 7027
• Pages: 764-769
• Publication date: 2005-02-01
• DOI: 10.1038/nature03269
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Microphthalmia-Associated Transcription Factor; Cell Cycle Proteins; Base Sequence; Melanocytes; Cells, Cultured; Phosphorylation; DNA-Binding Proteins; Animals; Transcription Factors; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cell Cycle; NIH 3T3 Cells; Melanoma; Mice; Humans; Protein Binding; Retinoblastoma Protein; Chromatin Immunoprecipitation; Transcriptional Activation