Pseudoporphyria and nonsteroidal antiinflammatory agents in children with juvenile idiopathic arthritis.

Journal article

Pseudoporphyria is characterized by erythema, blistering, and scarring on sun-exposed skin. Nonsteroidal antiinflammatory drugs (NSAIDs) are implicated in the etiology of this condition. In a 1-year prospective study of children attending the pediatric rheumatology clinic in Edinburgh we found a prevalence of pseudoporphyria of 10.9% in children taking NSAIDs for juvenile idiopathic arthritis. Naproxen was the most commonly implicated NSAID, independent of dosage. Blue/gray eye color was an independent risk factor for the development of pseudoporphyria. We would advise caution in prescribing naproxen in these children to prevent disfiguring facial scarring.

Authors: De Silva, B; Banney, L; Uttley, W; Luqmani, R; Schofield, O

• Publication status: Published
• Journal: Pediatric dermatology
• Volume: 17
• Issue: 6
• Pages: 480-483
• Publication date: 2000-01-01
• DOI: 10.1046/j.1525-1470.2000.01827.x
• EISSN: 1525-1470
• ISSN: 0736-8046
• Language: English
• Keywords: Porphyrias; Male; Prevalence; Female; Child; Humans; Anti-Inflammatory Agents, Non-Steroidal; Skin; Risk Factors; Prospective Studies; Arthritis, Juvenile Rheumatoid; Cohort Studies; Naproxen; Child, Preschool; Adolescent