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Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

Abstract:

Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while multiple clinical trials using this medication in the treatment of other malignancies are ongoing. As a clinical response to ipilimumab results from immunostimulation, predictab...

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Publication status:
Published

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Publisher copy:
10.1530/eje-12-0167

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
European journal of endocrinology / European Federation of Endocrine Societies More from this journal
Volume:
167
Issue:
1
Pages:
1-5
Publication date:
2012-07-01
DOI:
EISSN:
1479-683X
ISSN:
0804-4643
Language:
English
Keywords:
Pubs id:
pubs:322716
UUID:
uuid:eeb139bc-a1e2-4e44-a090-eb4e1413fcf9
Local pid:
pubs:322716
Source identifiers:
322716
Deposit date:
2012-12-19

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