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Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha.

Abstract:

The activation function 2/ligand-dependent interaction between nuclear receptors and their coregulators is mediated by a short consensus motif, the so-called nuclear receptor (NR) box. Nuclear receptors exhibit distinct preferences for such motifs depending both on the bound ligand and on the NR box sequence. To better understand the structural basis of motif recognition, we characterized the interaction between estrogen receptor alpha and the NR box regions of the p160 coactivator TIF2. We h...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m200764200

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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
24
Pages:
21862-21868
Publication date:
2002-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:eea31bac-557c-4e2d-8252-0cb0e4166a59
Source identifiers:
317571
Local pid:
pubs:317571

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